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What is Purpura Nephritis?

Purpura Nephritis is also known as Henoch-Schonlein Purpura (HSP). It is a whole-body disease which is caused by necrotizing vasculitis, and it can not only affect kidneys but also affect the whole organs. The clinical symptoms include skin purpura, joint gall, abdominal pain and hematochezia. However, the most obvious symptoms are hematuria and proteinuria which usually occurs after one month of the skin purpura presence. Purpura Nephritis develops to kidney failure easily, so once HSP patients found they have any symptom of kidney damage, they need to go to effective treatment as early as possible so as to prevent bad consequence.

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What causes Purpura Nephritis?

This disease is an allergic reaction which may be caused by bacteria, germs, parasite and other infections. Or it can be caused due to patients being allergic to some medications and foods and also can be related to plant pollen, bugbite and the stimulation of cold. It is usually accompanied by the following factors, including:

1. Infections

3/1 patients have the history of upper respiratory tract infection. The common pathogenes include virus which refers to Coxsackievirus, EB Virus, adenovirus, varicella-zoster virus and hepatitis B virus etc, as well as bacteria like salmonella, legionella, hemolytic and streptococcus. In addition, myoplasma, amoeba and worm can also cause infection leading to Purpura Nephritis.

2. Some medications and foods

Some medications may result in allergy and cause Purpura Nephritis. The medications are like antibiotics, sulfonamides, isoniazide and captopril. Some people may be allergic to some foods such as fish, crabs and shrimps. A long -term of allergy may lead to the allergic reaction of Purpura Nephritis.

3. Stimulation is related to purpura nephritis

Some people can not bear some stimulation, including cold, plant pollen, animal feathers, mosquitoes and vaccination. These stimulation can cause the presence of purpura nephritis.

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What is the pathogene of purpura nephritis?

Henoch-Schonlein purpura is a kind of systemic vasculitis disease which is mediated by immune complexes. Therefore, Purpura Nephritis also belongs to immune complex nephritis. And its onset is mainly through humoral immunity, but also involves the cellular immunity, some cytokines, inflammatory medium and clotting mechanism.

Besides, purpura nephritis has the tendency of ethnicity. And some medical researches show that this disease is related to heredity.

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What are the clinical symptoms?

1. Rash

It is the first and main clinical symptom which usually occurs in the distal limbs, hips and lower abdomen. The patients have the feeling of tickle and this feeling will disappear after 1-2 weeks.

2. Joints symptoms

They are the most common symptoms and patients usually have pain in their ankle joints.

3. Gastrointestinal symptoms

Purpura nephritis patients usually have abdominal pain, abdominal discomfort and diarrhea.

4. Kidney symptoms

The symptoms which kidneys show mainly include the abnormal urine, such as proteinuria and hematuria and some patients experience the decline of kidney function.

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The diagnosis of Purpura Nephritis

1. Routine urine test: for Purpura Nephritis patients, urinalysis always shows excessive protein and red blood cells in urine.

2. Routine blood test: blood test is used to show whether there are elevated metabolin like creatinine and urea nitrogen.

3. Kidney function test: it is used to show how well the kidney function is and this test involves urine specific gravity, creatinine, urea nitrogen,sediments and so on.

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What are the treatment for purpura nephritis

In order to avoid the relapse of purpura nephritis, patients need to take care of preventing upper respiratory infection and remove chronic infection lesions. Look for potential allergens and avoid touching it again.


Hormonotherapy is the most commonly seen treatment for immunological disease like Purpura Nephritis. With hormonotherapy, different kinds of immunosuppressive medicines are applied to block inflammatory response which occurs because IgA immune complexes or other immune complexes deposit in kidneys. Immunosuppressive medicines block iinflammatory response quickly and effectively, helping to prevent further kidney damage. However, immunosuppressive medicines fail to clear away immune complexes. In this case, when patients with purpura nephritis stop taking medicines or just reduce the dosage of immunosuppressive medicines, inflammatory response presents again. For this reason, new kidney damage occurs and purpura nephritis progresses.

Plasma Exchange

Plasma exchange is helpful in alleviating kidney damage and slowing down the progression of purpura nephritis, and this is because plasma exchange can clear away harmful substances like immune complexes from the body. However, simple plasma exchange treatment is far from enough for Purpura Nephritis patients living a future life without dialysis or kidney transplant.

Immunotherapy is a new treatment which is a combination of western medicines, plasma exchange and Chinese Herbal Treatment. It has six steps in the course of treating Purpura Nephritis, including immunodiagnosis, clearance of immune complexes, blocking of immoderate inflammatory reaction, immune tolerance, adjustment of immune system and protection of immune system.

With immunotherapy, kidney function can be improved and damaged but not necrotic cells can be activated. As long as kidney function is improved, Purpura Nephritis symptoms can be relieved and patients will feel better.

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Dietary principles for Purpura Nephritis

For patients with purpura nephritis, managing a well-planned diet is very important. In the course of Purpura Nephritis, patients need to have enough rest and pay attention to keep balance of water and electrolytes. Patients with edema and massive proteinuria should live a life with low salt, water limitation and protein restriction. The following dietary tips need patients to pay special attention.

First, purpura nephritis patients should eat some foods with light in taste and nourishing and easy to be absorded. Besides, patients should stay far away from high protein and high salt as well as greasy foods as these foods can worsen kidney damages.

Second, foods which can cause allergy such as crabs, shrimps and mutton should be avoided by purpura nephritis patients.

Third, foods should be highly processed, and this is because coarse foods can lead to bleeding of gastrointestinal tract.

Fourth, to be heathy, patients with purpura nephritis had better avoid wine and smoking.

Fifth, Purpura Nephritis patients with blood urine should avoid spicy and stimulating foods, such as chicken, seafoods, pepper, mutton and fish. They should eat some fruits and vegetables. Stay far away from sodium because heavy sodium will elevate blood pressure and aggravate the retention of water.

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