What Are The Manifestations Of Different Stage Of LupusThis article was provided by doctor zhengfalei 2018-09-18 09:14
To most lupus patients they are confused of reasonable treatments,and don’t know exactly what the manifestations of lupus Nephritis in different degrees are.
Lupus nephritis is an immune complex disease caused by endogenous ( self ) antigens, accompanied by T cell dysfunction. A variety of antibodies against autologous tissue components can be found in the serum of patients with lupus nephritis, among which the anti – DNA antibody, especially the anti – double – stranded DNA ( natural DNA ) antibody, plays a more positive role.The patient’s circulating immune complex can be separated into natural and single-stranded DNA antibodies and antigens. Immunoglobulin antibodies eluted from the patient’s glomeruli can bind to natural and single-stranded DNA antigens.
Lupus nephritis can occur at any stage of systemic lupus erythematosus, but it usually occurs within 1 – 4 years after the onset of systemic lupus erythematosus, and very few cases become the first manifestation of kidney disease. In addition to the general symptoms of systemic lupus erythematosus, such as fever, butterfly erythema and joint soreness, the patient also has clinical manifestations of kidney involvement.
According to the pathological changes and prognosis of lupus nephritis, the clinical manifestations can be roughly divided into four types:
I. Mild damage accounts for 35 % – 50 %. The clinical symptoms are not obvious, only the urine routine is abnormal, the albuminuria is + or + +, or the albuminuria is less than 1g every 24 hours, microscopic hematuria, normal or mild renal function decline.The prognosis is good.
2. Nephrotic syndrome accounts for about 20 %. A typical nephrotic syndrome, but with normal blood cholesterol, high blood pressure, moderate renal damage and poor prognosis.
Three, chronic nephritis accounted for 35 % – 50 %. There are hypertension, more albuminuria, a large number of red blood cells, a marked decrease in renal function and even renal failure.
Four, the rapid development of the disease, renal function quickly deteriorated. Urine protein and erythrocyte casts increase, often accompanied by fever and other lupus erythematosus activity. Often in a short period of time into renal failure.
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- Tag: Nephrotic Syndrome Chronic Nephritis Lupus patients Reasonable treatments DNA-antibody Immunoglobulin antibodies Mild damage account
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