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The Causes Of IgA Nephropathy

2013-08-24 10:45 IgA Nephropathy or Berger’s disease is a disorder of one’s immune system and is a kind of primary glomerular nephritis which is characterized by IgA or IgA antibodies deposition in glomerular mesangial area. Well, what are the causes of IgA Nephropathy? Follow us to find the answer.

IgA Nephropathy is regarded as a glomerular disease which is caused by deposition of immune complex. Its presence is related with the following factors:

1. Immune system disorder

IgA, standing for immunoglobulin A, is a normal part of your body’s immune system. When germs or bacteria attack your body, it will produce various antibodies to prevent your body from not having disease. However, due to disorder of your immune system, immunoglobulin A produced by your body will also be abnormal and when they combine with antigen, immune complexes will be formed. And they will deposit in glomerular membrane area through the circulation of blood and cause abnormal inflammation reaction in the kidneys. In this case, kidneys will be damaged partly and the surrounding tissues will also be injured. In this condition, red blood cells leak into urine, forming blood in urine which is called hematuria clinically.

2. Abnormal cellular inflammation factors

The IgA 1 in the mesangial area will lead to mesangial cells to secrete inflammatory factors and cause inflammatory reaction. In this way, renal structure and renal function will be damaged.

3. Bone marrow disorder

Bone marrow-derived also contributes to IgA deposition.

4. Genes

IgA Nephropathy is more common in some families and in certain ethnic groups

5. Infections

Infection usually will put you at a high risk of kidney failure and aggravate the conditions, including HIV infection and some bacteria infections.

6. Liver disease

It include cirrhosis, a condition in which scar tissue replaces normal tissue within the liver, and chronic hepatitis B and C infection.

The above are some causes of IgA Nephropathy and the main cause of IgA Nephropathy is your abnormal immune system. Therefore, you should use immunotherapy to clean up immune complexes, blocking inflammatory reaction and regulate your immune system so as to improve your kidney function.

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