How To Improve The Chronic Nephritis With High Blood Pressure2018-11-07 10:09
In the case of chronic nephritis, the remaining and / or diseased renal units are in a state of compensatory high hemodynamics. Systemic hypertension undoubtedly aggravates this condition and leads to progressive glomerular injury. Therefore, patients with chronic nephritis should actively control hypertension and prevent the deterioration of renal function. So what to do if chronic nephritis with high blood pressure occurs?
Angiotensin converting enzyme inhibitor as a first-line antihypertensive drug
The study suggests that although calcium antagonist has the function of slightly dilating the arterioles, it can significantly lower the blood pressure of the whole body, thus improving the high hemodynamics and metabolism of glomeruli that are not involved or only partially involved. In addition, the calcium antagonist reduces oxygen consumption, resists platelet aggregation, reduces calcium deposition in interstitial tissue and excessive oxidation of cell membrane through cell membrane effect, thus achieving the effects of reducing renal damage and stabilizing renal function.
Vasodilators such as hydralazine also have antihypertensive effects
It can be used in combination with beta-blockers to reduce the stimulation of renin by vasodilators? Angiotensin system and other side effects ( such as rapid heartbeat and retention of water and sodium ) can also improve the therapeutic effect. Hydralazine is generally 200 mg per day, but we must be alert to the possibility of the drug inducing lupus-like syndrome. For those with obvious edema, thiazine diuretics can be added if the renal function is good. For those with poor renal function ( serum creatinine ); 200 μ m ol / l ), thiazine drugs have poor or ineffective efficacy, and should be replaced by medullary loop diuretics. The application of diuretics should pay attention to electrolyte disorder in the body and the tendency to aggravate hyperlipidemia and hypercoagulability.
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