Statin Reduces Blood Lipid And Proteinuria In Kidney Disease
2019-05-27 10:20
Speaking of statins, you might think they are just lipid-lowering drugs. In fact, statins have more than lipid-lowering effects.
Statin not only reduces blood lipid, but also proteinuria.
When urinary protein leaks into the body, the liver synthesizes and replenishes more lipoproteins, which leads to increased blood lipids.
Therefore, patients with nephrotic syndrome who have a large amount of proteinuria often have hyperlipidemia and often need statins to reduce their lipids.
It is often seen in clinical treatment that statin is used in the treatment of nephrotic patients with reduced urinary protein.
Patients with low blood lipid nephropathy may ask, "Can I use statin to reduce urinary protein?"
In fact, the antiprotein effect of statins does not depend on lipid reduction. For patients with low blood lipid, statins can also play a role in reducing urinary protein.
Chronic nephritis, nephritis syndrome patients usually do not have too high urinary protein, such as 24-hour urinary protein quantitative 2 g or so patients, mostly without hyperlipidemia. After taking statins, urinary protein in these patients usually decreases significantly. That is to say, nephropathy patients without hyperlipidemia can also achieve the effect of protein reduction by taking statin.
Statin may reduce the risk of renal failure by reducing urinary protein through antioxidant, anti-inflammatory and inhibiting inflammatory cytokines.
Statin combined with pril/sartan in the treatment of urinary protein
Statins can be used in combination with sartan drugs, often reducing urinary protein by more than half. Twenty-four hours of urinary protein 2-3g patients, after combined treatment with statin and sartan, urinary protein decreased to less than 1g, so that the risk of renal damage is very small.
Some patients with good vascular conditions can also use the treatment of pril + sartan, the effect is better. However, the risk of adverse reactions of pril + sartan is high, and only a few nephrophiles are available.
In short, nephropathy patients must follow the doctor's advice.
Cautions for taking statin
Statins have few side effects, but they are not completely absent. For example, statin may cause myalgia and should be discontinued when myalgia occurs.
If the symptoms of myalgia persist after discontinuation, or if the pain is a single joint or a part of the body (such as arm or knee pain), the cause can be excluded and statin can be restarted.
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